Coronary arterial smooth muscle contraction by a substance released from platelets: evidence that it is thromboxane A2.

Ellis EF, Oelz O, Roberts LJ, Payne NA, Sweetman BJ, Nies AS, Oates JA
Science. 1976 193 (4258): 1135-7

PMID: 959827 · DOI:10.1126/science.959827

When human platelets are aggregated by thrombin, material is released that rapidly contracts strips of spirally cut porcine coronary artery. Prevention of the contraction by indomethacin suggested mediation by a prostaglandin. The contraction produced by aggregating platelets was unlike those produced by prostaglandins E2, F2alpha, G2, or H2, but resembled that evoked by thromboxane A2, which is formed by platelets during aggregation.

MeSH Terms (12)

Arteries Blood Platelets Coronary Circulation Humans Hydroxy Acids Male Muscle, Smooth Muscle Contraction Platelet Aggregation Prostaglandins Pyrans Vasoconstrictor Agents

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