Extracellular release of antigenic proteins by Helicobacter pylori.

Cao P, McClain MS, Forsyth MH, Cover TL
Infect Immun. 1998 66 (6): 2984-6

PMID: 9596777 · PMCID: PMC108299

Screening a Helicobacter pylori genomic library with antisera raised against H. pylori broth culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK, MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be released into the extracellular space by multiple mechanisms, including specific secretion pathways, autolysis, and membrane vesicle formation.

MeSH Terms (15)

Amino Acid Sequence Antigens, Bacterial Bacterial Proteins Escherichia coli Proteins Genomic Library Heat-Shock Proteins Helicobacter pylori Hemolysin Proteins HSP70 Heat-Shock Proteins Lipoproteins Membrane Transport Proteins Molecular Sequence Data Plasmids Sequence Analysis, DNA Sequence Homology, Amino Acid

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