Behavioral and demographic risk factors for transmission of human immunodeficiency virus type 1 in heterosexual couples: report from the Heterosexual HIV Transmission Study.

Skurnick JH, Kennedy CA, Perez G, Abrams J, Vermund SH, Denny T, Wright T, Quinones MA, Louria DB
Clin Infect Dis. 1998 26 (4): 855-64

PMID: 9564464 · DOI:10.1086/513929

We compared 224 heterosexual couples who were discordant for human immunodeficiency virus (HIV) type 1 infection (one partner HIV infected) with 78 HIV-concordant couples (both partners HIV infected) to identify demographic and behavioral risk factors for HIV transmission. Among the 229 couples whose male partner was first infected, HIV-concordant couples had engaged in anal sex more frequently before and after knowing that the male was infected than had HIV-discordant couples. Pap smears of grade 2 or higher (inflammation) were more prevalent among the second-infected female partners in HIV-concordant couples than among uninfected women in discordant couples (58% vs. 23%; P < .001). Anal sex and unprotected vaginal sex after knowledge of a male partner's infection were significant correlates of concordance in a multivariate logistic model, as were ethnicity, marital status, and antiviral therapy. Ethnicity strongly predicted concordance, even after controlling for sexual risk behaviors and stage of disease.

MeSH Terms (15)

Adult Aged Alcohol Drinking Female Heterosexuality HIV-1 HIV Infections Humans Male Middle Aged Multivariate Analysis Prospective Studies Risk Factors Sexual Partners Substance-Related Disorders

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