A functional magnetic resonance imaging study of tic suppression in Tourette syndrome.

Peterson BS, Skudlarski P, Anderson AW, Zhang H, Gatenby JC, Lacadie CM, Leckman JF, Gore JC
Arch Gen Psychiatry. 1998 55 (4): 326-33

PMID: 9554428 · DOI:10.1001/archpsyc.55.4.326

BACKGROUND - The inability to inhibit unwanted behaviors and impulses produces functional debility in a broad range of neuropsychiatric disorders. A potentially important model of impulse control is volitional tic suppression in Tourette syndrome.

METHODS - Tic suppression was studied in 22 adult subjects with Tourette syndrome by using functional magnetic resonance imaging. Images acquired during periods of voluntary tic suppression were compared with images acquired when subjects allowed the spontaneous expression of their tics. The magnitudes of signal change in the images were then correlated with measures of the severity of tic symptoms.

CONCLUSIONS - Significant changes in signal intensity were seen in the basal ganglia and thalamus and in anatomically connected cortical regions believed to subserve attention-demanding tasks. The magnitudes of regional signal change in the basal ganglia and thalamus correlated inversely with the severity of tic symptoms. These findings suggest that the pathogenesis of tics involves an impaired modulation of neuronal activity in subcortical neural circuits.

MeSH Terms (17)

Adolescent Adult Basal Ganglia Brain Brain Mapping Cerebral Cortex Disruptive, Impulse Control, and Conduct Disorders Female Humans Magnetic Resonance Imaging Male Middle Aged Models, Psychological Severity of Illness Index Sex Factors Tourette Syndrome Volition

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