Critical role of NK1+ T cells in IL-12-induced immune responses in vivo.

Kawamura T, Takeda K, Mendiratta SK, Kawamura H, Van Kaer L, Yagita H, Abo T, Okumura K
J Immunol. 1998 160 (1): 16-9

PMID: 9551949

CD1-dependent NK1+ T cells rapidly produce IL-4 upon stimulation through the TCR. These cells may therefore play an important role in the initiation of Th2 responses. Here, we show that NK1+ T cells constitutively express receptors for IL-12 and IFN-gamma, and that IL-12 induces production of perforin in these cells. Moreover, while IL-12 induces high levels of IFN-gamma and cytotoxic activity of hepatic or splenic mononuclear cells against tumor cells, this effect of IL-12 is significantly reduced in CD1-deficient mice with impaired NK1+ T cells development. These results indicate that NK1+ T cells play a critical role in IL-12-induced production of IFN-gamma to initiate Th1 immune responses and as IL-12-induced cytotoxic effector cells to initiate antitumor immunity.

MeSH Terms (23)

Animals Antigens Antigens, CD1 Antigens, Surface Cytotoxicity, Immunologic Fas Ligand Protein Interleukin-12 Lectins, C-Type Liver Male Membrane Glycoproteins Mice Mice, Inbred C57BL Mice, Knockout NK Cell Lectin-Like Receptor Subfamily B Perforin Pore Forming Cytotoxic Proteins Proteins Receptors, Interferon Receptors, Interleukin Receptors, Interleukin-12 T-Lymphocyte Subsets Up-Regulation

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