A critical, invariant chain-independent role for H2-M in antigen presentation.

Swier K, Brown DR, Bird JJ, Martin WD, Van Kaer L, Reiner SL
J Immunol. 1998 160 (2): 540-4

PMID: 9551884

Antigen presentation by MHC class II (class II) is facilitated by the accessory molecules, invariant chain (Ii) and H2-M. Ii associates with class II during biosynthesis and promotes transport of class II to Ag-loading compartments. One function of H2-M is the removal of Ii fragments from MHC class II. We have previously demonstrated that Ii-deficient mice, unlike class II-deficient mice, are resistant to L. major infection. In the present study, we found that H2-M-deficient (H2-M0) mice were susceptible to progressive infection with L. major. The dispensability of Ii for control of L. major allowed genetic analysis of whether H2-M functions by association with or independently of Ii. In contrast to Ii-deficient (Ii0) mice, Ii0H2-M0 mice were as susceptible to L. major as H2-M0 mice. Thus, H2-M has an essential, Ii-independent function during presentation of microbial pathogens.

MeSH Terms (12)

Animals Antigen Presentation Antigens, Differentiation, B-Lymphocyte Disease Susceptibility Histocompatibility Antigens Class II HLA-D Antigens Leishmania major Leishmaniasis, Cutaneous Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout

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