Disruption of IRS-2 causes type 2 diabetes in mice.

Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
Nature. 1998 391 (6670): 900-4

PMID: 9495343 · DOI:10.1038/36116

MeSH Terms (23)

Animals Blood Glucose Cloning, Molecular Diabetes Mellitus, Type 2 Female Gene Targeting Humans Insulin Insulin Receptor Substrate Proteins Insulin Resistance Intracellular Signaling Peptides and Proteins Islets of Langerhans Liver Male Mice Mice, Inbred C57BL Muscle, Skeletal Phosphatidylinositol 3-Kinases Phosphoproteins Phosphorylation Receptor, Insulin Recombination, Genetic Signal Transduction

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