Half corneal light shield as a delivery system for standardized application of mitomycin C.

Khoury JM, Joos KM, Shen JH, Davis D, O'Day DM
J Glaucoma. 1998 7 (1): 8-11

PMID: 9493108

PURPOSE - The authors develop a simple and economical method of applying reproducible intraoperative doses of mitomycin C for glaucoma filtering surgery.

METHODS - A three-part protocol was developed to study several properties of half corneal light shields (HCLSs). Part A tested the amount of mitomycin C (0.4 mg/ml) absorbed, the expansion dimensions attained, and the amount released to filter paper. In part B, the in vitro release of mitomycin C to an enucleated pig eye was examined. In part C, the in vivo release during intraoperative filtering surgery was tested.

RESULTS - The amount of mitomycin C solution absorbed by the HCLSs ranged from 1.07 x 10(-2) mg to 1.19 x 10(-2) mg; expansion width ranged from 6.8 mm to 7.0 mm; expansion height ranged from 3.6 mm to 3.8 mm; expansion thickness was constant at 0.6 mm. The amount of solution released to filter paper ranged from 6.8 x 10(-3) mg to 8.6 x 10(-3) mg. The amount of solution transferred to the pig eye ranged from 1.0 x 10(-3) mg to 2.7 x 10(-3) mg. The amount of solution released in filtering surgery ranged from 2.0 x 10(-3) mg to 4.8 x 10(-3) mg.

CONCLUSIONS - The contact surface area, the amount absorbed, and the amount released by each HCLS was reproducible. The uniform thickness theoretically provides a uniform distribution of mitomycin C. This method may allow standardization of intraoperative mitomycin C application, and may reduce the incidence of complications.

MeSH Terms (12)

Absorption Animals Antibiotics, Antineoplastic Cornea Drug Delivery Systems Filtering Surgery Glaucoma Humans Intraoperative Period Mitomycin Reproducibility of Results Swine

Connections (1)

This publication is referenced by other Labnodes entities: