Natural ligand of mouse CD1d1: cellular glycosylphosphatidylinositol.

Joyce S, Woods AS, Yewdell JW, Bennink JR, De Silva AD, Boesteanu A, Balk SP, Cotter RJ, Brutkiewicz RR
Science. 1998 279 (5356): 1541-4

PMID: 9488653 · DOI:10.1126/science.279.5356.1541

Mouse CD1d1, a member of the CD1 family of evolutionarily conserved major histocompatibility antigen-like molecules, controls the differentiation and function of a T lymphocyte subset, NK1+ natural T cells, proposed to regulate immune responses. The CD1d1 crystal structure revealed a large hydrophobic binding site occupied by a ligand of unknown chemical nature. Mass spectrometry and metabolic radiolabeling were used to identify cellular glycosylphosphatidylinositol as a major natural ligand of CD1d1. CD1d1 bound glycosylphosphatidylinositol through its phosphatidylinositol aspect with high affinity. Glycosylphosphatidylinositol or another glycolipid could be a candidate natural ligand for CD1d1-restricted T cells.

MeSH Terms (10)

Animals Antigens, CD1 Binding Sites Glycosylphosphatidylinositols Ligands Mass Spectrometry Mice Solubility Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization T-Lymphocyte Subsets

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