The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR
J Clin Invest. 1998 101 (2): 289-94

PMID: 9435299 · PMCID: PMC508566 · DOI:10.1172/JCI1269

MeSH Terms (12)

Animals ATP Binding Cassette Transporter, Subfamily B, Member 1 Caco-2 Cells HIV Protease HIV Protease Inhibitors Humans Indinavir Intestinal Absorption Male Mice Nelfinavir Saquinavir

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