The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin.

Dillon DA, D'Aquila T, Reynolds AB, Fearon ER, Rimm DL
Am J Pathol. 1998 152 (1): 75-82

PMID: 9422525 · PMCID: PMC1858125

Several studies have reported loss or alteration of expression of E-cadherin in breast cancer and more recently changes in levels of expression of the catenins. We used immunofluorescence to examine E-cadherin, alpha-catenin, beta-catenin, and p120ctn (formerly p120CAS) expression in 91 cases of invasive ductal carcinoma. As expected, all four proteins co-localize to the junctional regions of the cells. Although nuclear localization has been described for beta-catenin in colonic polyps, no examples were found in these breast cancer cases. We found that, although alteration is common in the catenins and E-cadherin, complete loss, as exemplified by E-cadherin in lobular carcinoma (where E-cadherin is frequently mutated), is rarely seen. In contrast, the catenin-related protein p120ctn shows an expression pattern that is significantly unrelated to the other catenins (or E-cadherin), including complete loss of expression in approximately 10% of the cases. No statistically significant correlations with traditional prognostic indicators were observed with any of these proteins. We conclude 1) that expression of E-cadherin and alpha- and beta-catenin are generally retained at the membrane although frequently reduced or altered, 2) that complete loss of p120ctn expression is seen in approximately 10% of the cases, and 3) that there is a significant correlation in the expression of E-cadherin and the catenins but no correlation between these molecules and p120ctn, suggesting an absence of coordinate regulation.

MeSH Terms (19)

Adult Aged Aged, 80 and over alpha Catenin beta Catenin Breast Neoplasms Cadherins Carcinoma, Ductal, Breast Catenins Cell Adhesion Molecules Cohort Studies Cytoskeletal Proteins Female Fluorescent Antibody Technique Humans Middle Aged Neoplasm Invasiveness Phosphoproteins Trans-Activators

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