Three-dimensional structures of proteins involved in programmed cell death.

Liang H, Fesik SW
J Mol Biol. 1997 274 (3): 291-302

PMID: 9405139 · DOI:10.1006/jmbi.1997.1415

Programmed cell death (apoptosis) is a controlled process by which unwanted cells are selectively eliminated. Several families of proteins including the Bcl-2, tumor necrosis factor receptor 1, and caspase families play essential roles in the regulation, signaling, and execution of the genetic cell death program. The recently described three-dimensional structures of members of these families elucidate the structural basis of their functions and provide insights into the mechanisms by which these proteins regulate apoptosis.

Copyright 1997 Academic Press Limited.

MeSH Terms (11)

Animals Apoptosis Caspase 3 Caspases Cysteine Endopeptidases Humans Models, Molecular Protein Conformation Proteins Proto-Oncogene Proteins c-bcl-2 Receptors, Tumor Necrosis Factor

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