NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.

Hajduk PJ, Dinges J, Miknis GF, Merlock M, Middleton T, Kempf DJ, Egan DA, Walter KA, Robins TS, Shuker SB, Holzman TF, Fesik SW
J Med Chem. 1997 40 (20): 3144-50

PMID: 9379433 · DOI:10.1021/jm9703404

MeSH Terms (19)

Antiviral Agents Binding Sites Biphenyl Compounds Bovine papillomavirus 1 Crystallography, X-Ray DNA DNA-Binding Proteins Drug Design Humans Ligands Magnetic Resonance Spectroscopy Models, Chemical Models, Molecular Papillomaviridae Protein Conformation Repressor Proteins Structure-Activity Relationship Trans-Activators Viral Proteins

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