Allele-sharing models: LOD scores and accurate linkage tests.

Kong A, Cox NJ
Am J Hum Genet. 1997 61 (5): 1179-88

PMID: 9345087 · PMCID: PMC1716027 · DOI:10.1086/301592

Starting with a test statistic for linkage analysis based on allele sharing, we propose an associated one-parameter model. Under general missing-data patterns, this model allows exact calculation of likelihood ratios and LOD scores and has been implemented by a simple modification of existing software. Most important, accurate linkage tests can be performed. Using an example, we show that some previously suggested approaches to handling less than perfectly informative data can be unacceptably conservative. Situations in which this model may not perform well are discussed, and an alternative model that requires additional computations is suggested.

MeSH Terms (11)

Alleles Chromosomes, Human, Pair 2 Computer Simulation Diabetes Mellitus, Type 2 Genetic Linkage Genetic Markers Humans Lod Score Mathematics Models, Genetic Software

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