Identification of a naturally occurring peroxidase-lipoxygenase fusion protein.

Koljak R, Boutaud O, Shieh BH, Samel N, Brash AR
Science. 1997 277 (5334): 1994-6

PMID: 9302294 · DOI:10.1126/science.277.5334.1994

A distant relative of catalase that is specialized for metabolism of a fatty acid hydroperoxide was identified. This heme peroxidase occurs in coral as part of a fusion protein, the other component of which is a lipoxygenase that forms the hydroperoxide substrate. The end product is an unstable epoxide (an allene oxide) that is a potential precursor of prostaglandin-like molecules. These results extend the known chemistry of catalase-like proteins and reveal a distinct type of enzymatic construct involved in the metabolism of polyunsaturated fatty acids.

MeSH Terms (17)

Amino Acid Sequence Animals Arachidonic Acid Binding Sites Catalase Catalysis Cloning, Molecular Cnidaria Hydrogen Peroxide Intramolecular Oxidoreductases Isomerases Lipoxygenase Molecular Sequence Data Peroxidase Peroxidases Recombinant Proteins Sequence Homology, Amino Acid

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