Endothelin in ischemic acute renal failure.

Hunley TE, Kon V
Curr Opin Nephrol Hypertens. 1997 6 (4): 394-400

PMID: 9263691 · DOI:10.1097/00041552-199707000-00015

The endothelin peptides comprise a family of potent and long-lasting vascoconstrictors, to which the renal microcirculation is particularly susceptible. Increased renal endothelin expression is observed after a variety of injurious stimuli, including ischemia, and persists for days after resolution of the initial injury. Autoinduction of its own production is likely to be a central mechanism underlying endothelin's prolonged effects. Furthermore, antagonizing endothelin reveals its role in maintaining the postischemic glomerular dysfunction that typifies ischemic acute renal failure.

MeSH Terms (7)

Acute Kidney Injury Animals Endothelins Humans Ischemia Kidney Receptors, Endothelin

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