Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling.

Ericson J, Rashbass P, Schedl A, Brenner-Morton S, Kawakami A, van Heyningen V, Jessell TM, Briscoe J
Cell. 1997 90 (1): 169-80

PMID: 9230312 · DOI:10.1016/s0092-8674(00)80323-2

Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.

MeSH Terms (23)

Animals Chick Embryo DNA-Binding Proteins Embryonic Induction Eye Proteins Hedgehog Proteins Homeodomain Proteins Interneurons Motor Neurons Nervous System Neurons Organ Culture Techniques Paired Box Transcription Factors PAX6 Transcription Factor Proteins Repressor Proteins Rhombencephalon Signal Transduction Spinal Cord Stem Cells Trans-Activators Transcription Factors Zebrafish Proteins

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