A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality.

Solorzano CC, Ksontini R, Pruitt JH, Auffenberg T, Tannahill C, Galardy RE, Schultz GP, MacKay SL, Copeland EM, Moldawer LL
Shock. 1997 7 (6): 427-31

PMID: 9185243 · DOI:10.1097/00024382-199706000-00007

MeSH Terms (12)

Animals Dipeptides Disease Models, Animal Endotoxins Female Humans Metalloendopeptidases Mice Mice, Inbred C57BL Protease Inhibitors Shock, Septic Tumor Necrosis Factor-alpha

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