Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: separation of blood volume and magnetic susceptibility effects.

Kennan RP, Scanley BE, Gore JC
Magn Reson Med. 1997 37 (6): 953-6

PMID: 9178248 · DOI:10.1002/mrm.1910370621

An NMR method is presented for separating blood volume and magnetic susceptibility effects in response to respiratory challenges such as hypoxia and hyperoxia. The technique employs high susceptibility contrast agents to enhance blood volume induced signal changes. The results show that for a rat model the dominant source of signal variation upon changing breathing gas from 100% oxygen to 10% oxygen/90% nitrogen is the change in blood magnetic susceptibility associated with the BOLD effect. The results imply that signal changes associated with respiratory challenges can be regarded as indicators of local blood oxygenation in vivo.

MeSH Terms (16)

Animals Blood Volume Brain Cerebrovascular Circulation Contrast Media Dextrans Ferrosoferric Oxide Hyperoxia Hypoxia Iron Magnetic Resonance Spectroscopy Magnetite Nanoparticles Oxides Oxygen Rats Rats, Sprague-Dawley

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