Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints.

Kingma PS, Greider CA, Osheroff N
Biochemistry. 1997 36 (20): 5934-9

PMID: 9166762 · DOI:10.1021/bi970507v

MeSH Terms (11)

Base Sequence Chromosomes, Human, Pair 11 DNA DNA Damage DNA Topoisomerases, Type II Humans Leukemia Molecular Sequence Data Recombinant Proteins Topoisomerase II Inhibitors Translocation, Genetic

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