Anatomy and function of the orbital frontal cortex, I: anatomy, neurocircuitry; and obsessive-compulsive disorder.

Zald DH, Kim SW
J Neuropsychiatry Clin Neurosci. 1996 8 (2): 125-38

PMID: 9081547 · DOI:10.1176/jnp.8.2.125

Many neuroimaging studies have implicated the orbital frontal cortex (OFC) in the pathophysiology of obsessive-compulsive disorder. In recent years there have been significant advances in elucidating the anatomical characteristics of the OFC in nonhuman primates. The authors review literature on the cytoarchitecture and afferent and efferent connections of the OFC, giving particular attention to the OFC's relationship to limbic and paralimbic regions, the mediodorsal thalamus, the basal ganglia, and sensory association cortices. These cytoarchitectural divisions and connections are discussed in terms of how they may influence thinking about the OFC's contribution to obsessive-compulsive disorder.

MeSH Terms (11)

Amygdala Basal Ganglia Frontal Lobe Humans Neural Pathways Obsessive-Compulsive Disorder Orbit Parietal Lobe Smell Taste Vision, Ocular

Connections (1)

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