Quinolones share a common interaction domain on topoisomerase II with other DNA cleavage-enhancing antineoplastic drugs.

Elsea SH, Westergaard M, Burden DA, Lomenick JP, Osheroff N
Biochemistry. 1997 36 (10): 2919-24

PMID: 9062121 · DOI:10.1021/bi962488f

MeSH Terms (20)

Amsacrine Animals Anti-Infective Agents Antineoplastic Agents Binding Sites CHO Cells Ciprofloxacin Cricetinae DNA, Superhelical DNA Topoisomerases, Type II Drosophila melanogaster Electrophoresis, Agar Gel Enzyme Activation Etoposide Fluoroquinolones Genistein Isoflavones Kinetics Molecular Structure Quinolones

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