An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective (14S,15R)-arachidonic acid epoxygenase.

Graham-Lorence S, Truan G, Peterson JA, Falck JR, Wei S, Helvig C, Capdevila JH
J Biol Chem. 1997 272 (2): 1127-35

PMID: 8995412 · DOI:10.1074/jbc.272.2.1127

MeSH Terms (14)

Animals Bacterial Proteins Binding Sites Cytochrome P-450 Enzyme System Gas Chromatography-Mass Spectrometry Mixed Function Oxygenases Models, Molecular Mutagenesis, Site-Directed NADP NADPH-Ferrihemoprotein Reductase Oxygenases Phenylalanine Stereoisomerism Valine

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