Regulation of differentiation by TGF-beta.

Moses HL, Serra R
Curr Opin Genet Dev. 1996 6 (5): 581-6

PMID: 8939725 · DOI:10.1016/s0959-437x(96)80087-6

Recent experiments in neural, skeletal, endothelial, and hematopoietic tissues have provided new insights into the way members of the transforming growth factor-beta (TGF-beta) superfamily regulate cellular differentiation. TGF-betas regulate the fate of multipotential stem cells instructively (in the neural crest) by regulating the expression or function of tissue-specific transcription factors, as well as selectively (in the mesenchyme) by regulating the expression of required growth factors and their receptors. During skeletal development, TGF-betas have unique functions and act sequentially to modulate chondrocyte and osteoblast differentiation. Responsiveness to TGF-betas changes as cells differentiate and evidence now suggests that changes in TGF-beta receptor profile may account for some of these differences. Drosophila and transgenic mouse models are now providing useful insights into mechanisms of TGF-beta action in vivo.

MeSH Terms (18)

Animals Blood Vessels Bone Marrow Bone Marrow Cells Bone Morphogenetic Proteins Cell Differentiation Drosophila melanogaster Endothelium, Vascular Gene Expression Regulation, Developmental Humans Inhibins Mammals Mice Mice, Transgenic Muscle, Skeletal Nervous System Nervous System Physiological Phenomena Transforming Growth Factor beta

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