Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates.

Guengerich FP, Yun CH, Macdonald TL
J Biol Chem. 1996 271 (44): 27321-9

PMID: 8910308 · DOI:10.1074/jbc.271.44.27321

MeSH Terms (13)

Alkylation Aniline Compounds Animals Cytochrome P-450 CYP2B1 Electrons Horseradish Peroxidase Kinetics Microsomes, Liver Models, Chemical Oxidation-Reduction Phenobarbital Rats Substrate Specificity

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