Evidence that abnormalities of central neurohormonal systems are key to understanding fibromyalgia and chronic fatigue syndrome.

Crofford LJ, Demitrack MA
Rheum Dis Clin North Am. 1996 22 (2): 267-84

PMID: 8860799 · DOI:10.1016/s0889-857x(05)70272-6

Fibromyalgia (FM) and chronic fatigue syndrome (CFS) fall into the spectrum of what might be termed stress-associated syndromes by virtue of frequent onset after acute or chronic stressors and apparent exacerbation of symptoms during periods of physical or emotional stress. These illnesses also share perturbation of the hypothalamic-pituitary-adrenal axis and sympathetic stress response systems. In this article, the authors discuss the specific neurohormonal abnormalities found in FM and CFS and potential mechanisms by which dysfunction of neurohormonal stress-response systems could contribute to vulnerability to stress-associated syndromes and to the symptoms of FM and CFS.

MeSH Terms (6)

Humans Hypothalamo-Hypophyseal System Models, Biological Neurotransmitter Agents Pituitary-Adrenal System Sympathetic Nervous System

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