Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI.

Chen Q, Andersen AH, Zhang Z, Ovadia A, Gash DM, Avison MJ
Magn Reson Imaging. 1996 14 (5): 469-76

PMID: 8843359

A multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R2*) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP). R2* decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R2* decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R2* change support the view that the method is monitoring changes in neural activity.

MeSH Terms (10)

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Brain Brain Mapping Carbidopa Female Levodopa Macaca mulatta Magnetic Resonance Imaging Parkinson Disease, Secondary

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