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Strategies in the treatment of diffuse pontine gliomas: the therapeutic role of hyperfractionated radiotherapy and chemotherapy.

Jennings MT, Freeman ML, Murray MJ
J Neurooncol. 1996 28 (2-3): 207-22

PMID: 8832463 · DOI:10.1007/bf00250200

This article will review the current treatment of pediatric patients with diffuse pontine gliomas (DPG) and discuss three potential avenues of therapeutic research including (i) radiotherapy (RT) in combination with radiation sensitizers, (ii) dose-intensive, induction chemotherapy with hematopoietic support followed in sequence with RT applied as a "consolidation' therapy, and (iii) the interleafed application of phase-specific chemotherapeutic agents and hyperfractionated external beam radiotherapy (HFEBRT) referred to as "chemoradiotherapy'.

MeSH Terms (11)

Antineoplastic Agents Brain Neoplasms Child Combined Modality Therapy Glioma Hematopoietic Stem Cell Transplantation Humans Pons Prognosis Radiation-Sensitizing Agents Radiotherapy Dosage

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