Lymphoid involvement in a patient with acute myeloid leukemia: a direct phenotypic and genotypic study of single cells.

El-Rifai W, Larramendy ML, Ruutu T, Knuutila S
Genes Chromosomes Cancer. 1996 15 (1): 34-7

PMID: 8824723 · DOI:10.1002/(SICI)1098-2264(199601)15:1<34::AID-GCC5>3.0.CO;2-5

Lymphoid involvement in acute myeloid leukemia (AML) was studied using the morphology-antibody-chromosome (MAC) combination technique in one patient. The chromosomal aberration, trisomy 8, was demonstrated in AML blasts, glycophorin A-positive erythroblasts, and CD3- and CD20/22-positive small lymphocytes. This suggests that in this patient even lymphocytes belonged to the leukemic clone.

MeSH Terms (12)

Acute Disease Aged Cell Differentiation Chromosomes, Human, Pair 8 Female Genotype Humans Immunophenotyping Leukemia, Myeloid Phenotype Trisomy Tumor Cells, Cultured

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