Phosphatidylinositol 4,5-bisphosphate binding to the pleckstrin homology domain of phospholipase C-delta1 enhances enzyme activity.

Lomasney JW, Cheng HF, Wang LP, Kuan Y, Liu S, Fesik SW, King K
J Biol Chem. 1996 271 (41): 25316-26

PMID: 8810295 · DOI:10.1074/jbc.271.41.25316

MeSH Terms (19)

Binding Sites Blood Proteins Enzyme Activation Humans Hydrolysis Isoenzymes Kinetics Micelles Mutagenesis Mutagenesis, Site-Directed Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositols Phospholipase C delta Phospholipids Phosphoproteins Point Mutation Recombinant Proteins Sequence Deletion Type C Phospholipases

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