Germinal center formation in mice lacking alpha beta T cells.

Dianda L, Gulbranson-Judge A, Pao W, Hayday AC, MacLennan IC, Owen MJ
Eur J Immunol. 1996 26 (7): 1603-7

PMID: 8766567 · DOI:10.1002/eji.1830260729

T cells are essential for inducing clonal B cell expansion in germinal centers during T cell-dependent antibody responses. However, class-switched antibodies are readily detectable in TCR alpha-deficient mice that congenitally lack alpha beta T cells, including those such as IgG1 that are considered to be dependent on collaboration between B cells and alpha beta T cells. This observation suggests that a novel form of B:T collaboration may be evident in TCR alpha-/- mice. We report that germinal centers develop spontaneously in mice lacking T cell receptor alpha genes (TCR alpha-/-), despite the absence of alpha beta T cells. They are not seen in TCR beta-/- mice kept in similar conditions. Both strains of mice have gamma delta T cells, but it is a subset of T cells expressing TCR beta and CD4 that is dominant in the germinal centers of TCR alpha-/- mice. Exceptionally, germinal centers were associated with CD4+ gamma delta T cells. The expression of CD4 seems to be important, for few extrafollicular T cells have CD4 and CD4 is largely absent from TCR beta-/- T cells. The CD4+ TCR beta cells may help B cells produce autoantibodies that have been identified in TCR alpha-/- mice.

MeSH Terms (9)

Animals B-Lymphocytes Clone Cells Germinal Center Lymphocyte Cooperation Mice Mice, Mutant Strains Receptors, Antigen, T-Cell, alpha-beta T-Lymphocyte Subsets

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