Regulation of cathepsin E expression during human B cell differentiation in vitro.

Sealy L, Mota F, Rayment N, Tatnell P, Kay J, Chain B
Eur J Immunol. 1996 26 (8): 1838-43

PMID: 8765029 · DOI:10.1002/eji.1830260826

Cathepsin E is an aspartic proteinase which has been implicated in antigen processing in the class II major histocompatibility complex pathway. In this study we show that cathepsin E, measured at both the protein and message level, is up-regulated late in human B cell activation. The implications of this observation in terms of cathepsin E function are discussed.

MeSH Terms (18)

Adolescent Adult B-Lymphocytes Base Sequence Cathepsin E Cathepsins Cell Differentiation Cell Line Child Child, Preschool Epitopes Humans Infant Lymphocyte Activation Molecular Sequence Data Palatine Tonsil RNA, Messenger T-Lymphocytes

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