DNA copy number losses in chromosome 14: an early change in gastrointestinal stromal tumors.

el-Rifai W, Sarlomo-Rikala M, Miettinen M, Knuutila S, Andersson LC
Cancer Res. 1996 56 (14): 3230-3

PMID: 8764113

The DNA copy number changes were investigated in 13 malignant, 3 borderline, and 16 benign gastrointestinal stromal tumors (GISTs) by comparative genomic hybridization. A consistent finding was the loss of DNA copy numbers in chromosome 14q. This was detected in 75% of the benign tumors, in 62% of the malignant tumors, and in two out of the three borderline tumors with a minimal overlapping region located to 14q22. Losses of DNA copy numbers were more frequent than gains, with 2-10 changes in malignant GISTs and 1-3 changes in benign tumors. High-level DNA amplifications, detected only in malignant GISTs, were assigned to 3q26-q29 (40%), 5p (30%), and 8q22-24 (40%). Our results indicate that copy number losses in 14q are an early change during oncogenesis of GISTs and suggest the possibility that a new tumor suppressor gene at 14q22 might be involved in the regulation of differentiation or proliferation of such mesenchymal cells.

MeSH Terms (16)

Adult Aged Chromosome Aberrations Chromosome Disorders Chromosome Mapping Chromosomes, Human, Pair 14 DNA, Neoplasm Female Gastrointestinal Neoplasms Gene Amplification Humans Male Mesoderm Middle Aged Nucleic Acid Hybridization Sequence Deletion

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