Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation.

Tateishi T, Krivoruk Y, Ueng YF, Wood AJ, Guengerich FP, Wood M
Anesth Analg. 1996 82 (1): 167-72

PMID: 8712396 · DOI:10.1097/00000539-199601000-00031

MeSH Terms (20)

Analgesics, Opioid Animals Antibodies Antibody Specificity Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Dealkylation Enzyme Inhibitors Erythromycin Fentanyl Humans Kinetics Liver Microsomes, Liver Mixed Function Oxygenases Norpregnenes Rabbits Sufentanil Troleandomycin

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