Tumor antigen and human chorionic gonadotropin in CaSki cells: a new epidermoid cervical cancer cell line.

Pattillo RA, Hussa RO, Story MT, Ruckert AC, Shalaby MR, Mattingly RF
Science. 1977 196 (4297): 1456-8

PMID: 867042 · DOI:10.1126/science.867042

Epidermoid cervical carcinoma cells (CaSki line) have been established in continuous culture. When leukocytes from cervical cancer patients were incubated with CaSki culture fluid concentrates, inhibition of leukocyte migration was observed in more than 70 percent of the patients tested. By contrast, significantly less inhibition was observed with normal donor leukocytes or leukocytes from patients with other types of cancer. These results were consistent with the expression of tumor-associated antigen by CaSki cells. Analysis of the serum from the donor of the cell line at the time of tumor biopsy, and of CaSki culture fluids, demonstrated the presence of the beta subunit of human chorionic gonadotropin.

MeSH Terms (10)

Adult Antigens, Neoplasm Cell Line Cell Migration Inhibition Chorionic Gonadotropin Culture Media Female Humans Leukocytes Uterine Cervical Neoplasms

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