Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.

Lechleider RJ, de Caestecker MP, Dehejia A, Polymeropoulos MH, Roberts AB
J Biol Chem. 1996 271 (30): 17617-20

PMID: 8663601 · DOI:10.1074/jbc.271.30.17617

The transforming growth factor-beta (TGF-beta) superfamily regulates a multitude of cellular and developmental events. TGF-beta family ligands signal through transmembrane serine/threonine kinase receptors whose downstream effectors are largely unknown. Using genetic data from the fruit fly, we have identified a downstream effector of TGF-beta-induced signaling. TGF-beta signaling protein-1 (BSP-1) is rapidly phosphorylated in response to TGF-beta. Localization of bsp-1 to chromosome 4q28 suggests a role in carcinogenesis. These data suggest that BSP-1 is the prototype of a new class of signaling molecules.

MeSH Terms (18)

Amino Acid Sequence Base Sequence Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Chromosome Mapping Chromosomes, Human, Pair 4 Cloning, Molecular DNA-Binding Proteins Humans Molecular Sequence Data Phosphorylation Proteins Repressor Proteins Sequence Homology, Amino Acid Serine Signal Transduction Smad Proteins Trans-Activators Transforming Growth Factor beta

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