The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.

Hiebert SW, Sun W, Davis JN, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussell MF, Gilliland DG, Lenny N, Meyers S
Mol Cell Biol. 1996 16 (4): 1349-55

PMID: 8657108 · PMCID: PMC231119 · DOI:10.1128/MCB.16.4.1349

MeSH Terms (16)

Base Sequence Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 21 DNA-Binding Proteins Enhancer Elements, Genetic Helix-Loop-Helix Motifs Humans Leukemia Molecular Sequence Data Proto-Oncogene Proteins c-ets Recombinant Fusion Proteins Repressor Proteins Sequence Deletion Transcription, Genetic Transcription Factors Translocation, Genetic

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