Expression and functional expansion of fibroblast growth factor receptor T cells in rheumatoid synovium and peripheral blood of patients with rheumatoid arthritis.

Byrd V, Zhao XM, McKeehan WL, Miller GG, Thomas JW
Arthritis Rheum. 1996 39 (6): 914-22

PMID: 8651984 · DOI:10.1002/art.1780390607

OBJECTIVE - Rheumatoid arthritis (RA) is an inflammatory disorder of the diarthroidial joints, characterized by fibroblast proliferation, angiogenesis, and perivascular CD4+ T cell infiltration. The present study examined the interactions between fibroblast growth factor-1 (FGF-1) and T cells.

METHODS - Synovial tissues from patients with RA or noninflammatory arthritis were examined for the expression of FGF-1 and its receptor, FGFR-1, by immunohistology and reverse transcriptase-polymerase chain reaction. Functional assays were used to detect enrichment of FGF-1-responsive peripheral CD4+ T cells in RA.

RESULTS - FGF-1 is abundantly expressed by rheumatoid synovium. Enhanced expression of its receptor, FGFR-1, was found in perivascular CD4+ T cells. In addition, T cells that are activated by FGF-1 are increased in the peripheral blood of patients with RA, as compared with other inflammatory conditions.

CONCLUSION - The increased frequency of peripheral T cells that respond to FGF-1 in RA is consistent with expansion of FGFR-1-expressing T cells in the rheumatoid synovium.

MeSH Terms (11)

Arthritis, Rheumatoid Base Sequence CD4-Positive T-Lymphocytes Fibroblast Growth Factors Humans Molecular Sequence Data Receptor, Fibroblast Growth Factor, Type 1 Receptor Protein-Tyrosine Kinases Receptors, Fibroblast Growth Factor Synovial Membrane T-Lymphocytes

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