Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.

Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhäuser N, Böhm-Matthaei R, Baeuerle PA, Barde YA
Science. 1996 272 (5261): 542-5

PMID: 8614802 · DOI:10.1126/science.272.5261.542

Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) selectively bind to distinct members of the Trk family of tyrosine kinase receptors, but all three bind with similar affinities to the neurotrophin receptor p75 (p75NTR). The biological significance of neurotrophin binding to p75NTR in cells that also express Trk receptors has been difficult to ascertain. In the absence of TrkA, NGF binding to p75NGR activated the transcription factor nuclear factor kappa B (NF-kappa B) in rat Schwann cells. This activation was not observed in Schwann cells isolated from mice that lacked p75NTR. The effect was selective for NGF; NF-kappa B was not activated by BDNF or NT-3.

MeSH Terms (21)

Animals Base Sequence Brain-Derived Neurotrophic Factor Cell Nucleus Cells, Cultured DNA L Cells Mice Molecular Sequence Data Nerve Growth Factors Nerve Tissue Proteins Neurotrophin 3 NF-kappa B Proto-Oncogene Proteins Rats Receptor, Nerve Growth Factor Receptor, trkA Receptor Protein-Tyrosine Kinases Receptors, Nerve Growth Factor Schwann Cells Signal Transduction

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