The width of the minor groove affects the binding of the bisquaternary heterocycle SN-6999 to duplex DNA.

Rydzewski JM, Leupin W, Chazin W
Nucleic Acids Res. 1996 24 (7): 1287-93

PMID: 8614632 · PMCID: PMC145775 · DOI:10.1093/nar/24.7.1287

MeSH Terms (11)

Antineoplastic Agents Base Sequence Binding Sites DNA Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Oligodeoxyribonucleotides Quinolinium Compounds Structure-Activity Relationship

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