Myeloid lineage involvement in acute lymphoblastic leukemia: a morphology antibody chromosomes (MAC) study.

Larramendy M, el-Rifai W, Saarinen U, Alitalo R, Luomahaara S, Knuutila S
Exp Hematol. 1995 23 (14): 1563-7

PMID: 8542947

We looked for clonal chromosomal abnormalities in myeloid cell lineages in the bone marrow aspirates from six children with acute lymphoblastic leukemia (ALL). The study was carried out using a combination of MAC (morphology, antibody, chromosomes) and in situ hybridization procedures. In patients whose leukemic cells expressed only lymphoid antigens, we found chromosomal aberrations in CD10- and CD20/22-positive lymphoid cells. Mature CD22+ and CD3+ lymphocytes did not have the chromosomal aberrations. In one patient whose leukemic cells also expressed myeloid-associated antigens, the clonal chromosome aberrations were seen not only in the CD10+ and CD19+ blasts, but also in glycophorin A-positive morphologically nonleukemic erythroblasts.

MeSH Terms (23)

Antigens, CD Antigens, CD19 Antigens, CD20 Antigens, Differentiation, B-Lymphocyte Antigens, Differentiation, Myelomonocytic CD3 Complex Cell Adhesion Molecules Child, Preschool Chromosome Aberrations Chromosome Banding Female Granulocytes Humans Immunophenotyping In Situ Hybridization Karyotyping Lectins Lipopolysaccharide Receptors Male Neprilysin Precursor Cell Lymphoblastic Leukemia-Lymphoma Sialic Acid Binding Ig-like Lectin 2 Sialic Acid Binding Ig-like Lectin 3

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