Sequence-specific oligonucleotide typing in Shona patients with rheumatoid arthritis and healthy controls from Zimbabwe.

Cutbush S, Chikanza IC, Biro PA, Bekker C, Stein M, Lutalo S, Garcia-Pacheco JM, McCloskey DS, Lanchbury JS, Sachs JA
Tissue Antigens. 1993 41 (4): 169-72

PMID: 8362408 · DOI:10.1111/j.1399-0039.1993.tb01997.x

Seventy-two patients with rheumatoid arthritis (RA) and 82 controls have been typed with the XI Histocompatibility Workshop DRB1 and DQB1 sequence-specific oligonucleotide probes. The increase of DRB1*04 corresponds to an increase of the serologically defined DR4, previously found in a small group of Zimbabwean RA patients and we now show that this increase is due to the subtype DRB1*0405 in association with DQB1*0302. In addition there is a clearcut increase of DRB1*1001 equivalent to the serologically defined DR10. There was no increase amongst RA patients of DRB1*0102 which was the predominant DR1 sub-type amongst controls. In the course of our investigation, we observed a DRB1*04 variant which corresponds to DRB1*0412, newly defined in the XIth Histocompatibility Workshop.

MeSH Terms (14)

Arthritis, Rheumatoid Base Sequence DNA Genetic Variation Histocompatibility Antigens Class II HLA-DQ Antigens HLA-DQ beta-Chains HLA-DR Antigens HLA-DRB1 Chains Humans Oligonucleotide Probes Polymorphism, Genetic South Africa Zimbabwe

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