K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung.

Westra WH, Slebos RJ, Offerhaus GJ, Goodman SN, Evers SG, Kensler TW, Askin FB, Rodenhuis S, Hruban RH
Cancer. 1993 72 (2): 432-8

PMID: 8319174 · DOI:10.1002/1097-0142(19930715)72:2<432::aid-cncr2820720219>3.0.co;2-#

MeSH Terms (13)

Adenocarcinoma Aged Female Gene Expression Regulation, Neoplastic Genes, ras Humans Lung Neoplasms Male Middle Aged Point Mutation Polymerase Chain Reaction Smoking Time Factors

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