Analysis of an insulin gene transcription control element. Positive and negative regulation appears to be mediated by different element sequences.

Stein R, Henderson E, Cordle SR
FEBS Lett. 1994 338 (2): 187-90

PMID: 8307179 · DOI:10.1016/0014-5793(94)80362-5

Pancreatic beta-cell-type-specific transcription of the insulin gene is controlled by cis-acting sequence elements lying within its enhancer region. An essential element required for expression is the insulin control element (ICE). The activity of this element is regulated by both positive- and negative-acting transcription factors. In this study, we have identified the nucleotide sequences within the ICE that are required for repression in noninsulin producing cells. Our results indicate that the cis-acting sequences involved in negative control are distinct from those required in activating expression in beta cells.

MeSH Terms (14)

Animals Base Composition Base Sequence Cricetinae Gene Expression Regulation HeLa Cells Humans Insulin Kidney Molecular Sequence Data Point Mutation Regulatory Sequences, Nucleic Acid Repressor Proteins Transcription, Genetic

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