Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential.

Elsea SH, McGuirk PR, Gootz TD, Moynihan M, Osheroff N
Antimicrob Agents Chemother. 1993 37 (10): 2179-86

PMID: 8257142 · PMCID: PMC192247 · DOI:10.1128/AAC.37.10.2179

MeSH Terms (14)

Animals Anti-Infective Agents Cattle Cell Death Cells, Cultured CHO Cells Cricetinae DNA Fluoroquinolones Humans Nucleic Acid Conformation Quinolones Structure-Activity Relationship Topoisomerase II Inhibitors

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