Inherited enhancement of hydroxyl radical generation and lipid peroxidation in the S strain rats results in DNA rearrangements, degenerative diseases, and premature aging.

Salganik RI, Solovyova NA, Dikalov SI, Grishaeva ON, Semenova LA, Popovsky AV
Biochem Biophys Res Commun. 1994 199 (2): 726-33

PMID: 8135816 · DOI:10.1006/bbrc.1994.1289

Previously by selection and inbreeding of Wistar rats susceptible or resistant to the cataractogenic effect of galactose the S and R rat strains differing in the intensity of hexose transport into the animal cells were developed. High level of OH-radical generation and enhanced lipid peroxidation are revealed in the liver and myocardium of the S rats in contrast to the R rats. Data are obtained supporting the view that enhanced generation of OH-radicals within the S rat tissues is due to oxidation and autooxidation of the abundant amounts of monosacharides intensely accumulating in the rat cells. In spite of continuous inbreeding for more than 40 generations and a high rate of homozygosity, numerous DNA rearrangements are revealed in the S rat genomes. Fragility of the S rat cell membranes is detected. Cataracts and other lens lesions, emphysema, tumors, cardiomyopathy-like changes in the myocardium, scoliosis, brain disfunctions are characteristic of the S rats, as well as low fertility and short life-span indicative of premature aging.

MeSH Terms (23)

Aging Animals Cataract DNA Female Fertility Genetic Predisposition to Disease Heart Hydroxyl Radical Intracellular Membranes Lipid Peroxidation Liver Longevity Lysosomes Male Mitochondria, Heart Mitochondria, Liver Myocardium Radiography Rats Rats, Mutant Strains Rats, Wistar Spinal Cord

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