Satisfactorily attenuated and protective mutants derived from a partially attenuated cold-passaged respiratory syncytial virus mutant by introduction of additional attenuating mutations during chemical mutagenesis.

Crowe JE, Bui PT, London WT, Davis AR, Hung PP, Chanock RM, Murphy BR
Vaccine. 1994 12 (8): 691-9

PMID: 8091846 · DOI:10.1016/0264-410x(94)90218-6

MeSH Terms (19)

Animals Cell Line Chlorocebus aethiops Cold Temperature Female Humans Male Mice Mice, Inbred BALB C Mice, Nude Mutagenesis Pan troglodytes Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Serial Passage Vaccines, Attenuated Vero Cells Viral Vaccines Virus Replication

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