The anemia of primary autonomic failure and its reversal with recombinant erythropoietin.

Biaggioni I, Robertson D, Krantz S, Jones M, Haile V
Ann Intern Med. 1994 121 (3): 181-6

PMID: 8017744 · DOI:10.7326/0003-4819-121-3-199408010-00004

OBJECTIVE - To determine if chronic sympathetic deprivation is associated with anemia and a low erythropoietin response.

DESIGN - Survey of the prevalence and characteristics of anemia in patients with severe primary autonomic failure.

SETTING - A referral service for autonomic failure in a tertiary teaching hospital.

PATIENTS - 84 patients with primary autonomic failure who had symptomatic orthostatic hypotension.

INTERVENTION - Open-label trial with human recombinant erythropoietin.

RESULTS - Anemia was present in 32 of 84 patients (38%; 95% Cl, 27% to 50%). Plasma norepinephrine levels, measured in patients standing upright, were lower in the patient group with lower hemoglobin levels. Mean values in 22 patients with a hemoglobin level of less than 120 g/L were as follows: hemoglobin, 108 g/L (range, 87 to 118 g/L); hematocrit, 0.33; corrected reticulocyte counts, 0.008; mean corpuscular volume, 89 fL (89 microns 3); serum iron, 16.5 mumol/L (92 micrograms/dL); total iron binding capacity, 43.3 mumol/L (242 micrograms/dL); ferritin, 184 micrograms/L; serum vitamin B12, 410 pmol/L (556 pg/mL); and serum folate, 22.7 nmol/L (10 ng/mL). No relation was found between serum erythropoietin and blood hemoglobin levels. In seven of nine patients with autonomic failure who had hemoglobin levels less than 120 g/L, serum erythropoietin levels decreased below the 95% confidence interval corresponding to patients with iron deficiency anemia. Therapy with recombinant erythropoietin improved mean hemoglobin levels (from 108 to 133 g/L) in all patients treated (n = 5) at relatively low doses (25 to 50 units/kg body weight, subcutaneously, three times a week).

CONCLUSIONS - Our data support the hypothesis that the sympathetic nervous system stimulates erythropoiesis in humans because anemia is a frequent occurrence in patients with severe autonomic failure and is associated with a blunted erythropoietin response.

MeSH Terms (11)

Aged Analysis of Variance Anemia Autonomic Nervous System Diseases Erythropoietin Female Humans Male Middle Aged Recombinant Proteins Severity of Illness Index

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