Pathology of glomerular basement membrane nephropathy.

Hudson BG, Kalluri R, Tryggvason K
Curr Opin Nephrol Hypertens. 1994 3 (3): 334-9

PMID: 7922261 · DOI:10.1097/00041552-199405000-00016

Studies of the molecular pathology of glomerular basement membrane have led to the discovery of four novel chains of type IV collagen, the latest of which is the alpha 6(IV) chain. Three chains have been shown to be directly involved in the pathogenesis of Goodpasture syndrome, Alport syndrome, and Alport posttransplantation antiglomerular basement membrane nephritis. This review focuses on the novel chains with respect to recent advances in their structure, gene organization, and involvement in the pathogenesis of these glomerulopathies.

MeSH Terms (10)

Amino Acid Sequence Animals Anti-Glomerular Basement Membrane Disease Basement Membrane Collagen Glomerulonephritis Humans Kidney Glomerulus Molecular Sequence Data Nephritis, Hereditary

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