Metabotropic glutamate receptor-induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells.

Desai MA, McBain CJ, Kauer JA, Conn PJ
Neurosci Lett. 1994 181 (1-2): 78-82

PMID: 7898776 · DOI:10.1016/0304-3940(94)90564-9

Previous studies suggest that activation of metabotropic glutamate receptors (mGluRs) reduces GABA-mediated synaptic inhibition in area CA1 of the hippocampus. However, the mechanisms involved in this disinhibition are not known. We report that mGluR activation reduces both the GABAA and GABAB receptor-mediated components of evoked inhibitory postsynaptic potentials (IPSPs) by reducing transmission at excitatory synapses onto inhibitory interneurons and inhibitory synapses onto CA1 pyramidal cells.

MeSH Terms (12)

Animals Cycloleucine Electric Stimulation Interneurons Male Neural Inhibition Pyramidal Cells Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate Synapses Synaptic Transmission

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